Limela tsa setso tsa meriana li 'nile tsa nkoa e le tsa bohlokoa ho theosa le lilemo bakeng sa ho fana ka temohisiso mabapi le letoto la mafu.Leha ho le joalo, ho arola limolek'hule tse itseng tse sebetsang hantle sebakeng sa metsoako e etsang mefuta e mengata ea limela e ka ba mosebetsi o boima.Hona joale, bafuputsi Univesithing ea Toyama, Japane ba thehile mokhoa oa ho arola le ho khetholla metsoako e sebetsang meriana ea limela.
Lintlha tse ncha-e phatlalalitsoeng haufinyane ho Frontiers in Pharmacology sengolong se nang le sehlooho se reng, “Leano la Taolo ea ho Fumana Sethethefatsi sa Phekolo bakeng sa Lefu la Alzheimer le Molek'hule ea Lona", bontša hore mokhoa o mocha o khetholla metsoako e 'maloa e sebetsang e tsoang ho Drynaria rhizome, moriana oa setso oa semela, o ntlafatsang mohopolo le ho fokotsa litšobotsi tsa mafu mofuteng oa mouse oa lefu la Alzheimer's.
Ka tloaelo, bo-ramahlale ba tla hlahloba khafetsa meriana ea limela tse tala litekong tsa laborateng ho bona hore na ho na le metsoako e bontšang phello liseleng tse holileng ka har'a vitro.Haeba motsoako o bontša phello e ntle liseleng kapa li-tubes tsa teko, o ka sebelisoa e le sethethefatsi, 'me bo-rasaense ba tsoela pele ho e hlahloba liphoofolong.Leha ho le joalo, tšebetso ena e boima ’me ha e ikarabelle bakeng sa liphetoho tse ka bang teng litlhare ha li kena ’meleng—li-enzyme tse maling le sebeteng li ka fetola meriana ka mefuta e sa tšoaneng e bitsoang metabolites.Ho feta moo, likarolo tse ling tsa 'mele, joalo ka boko, ho thata ho li fumana bakeng sa lithethefatsi tse ngata, 'me ke lithethefatsi tse itseng feela kapa metabolite ea tsona e tla kena liseleng tsena.
"Metsoako ea bonkgetheng e bonts'itsoeng litsing tsa litlama tsa setso tsa meriana ea limela ha se kamehla e leng metsoako ea 'nete hobane litlhahlobo tsena li hlokomoloha biometabolism le kabo ea lisele," ho hlalositse mofuputsi e moholo Chihiro Tohda, Ph.D., motlatsi oa moprofesa oa neuropharmacology Univesithing ea Toyama. ."Kahoo, re ne re ikemiselitse ho hlahisa mekhoa e sebetsang haholoanyane ea ho tseba metsoako ea 'nete e sebetsang e nahanelang lintlha tsena."
Phuputsong, sehlopha sa Toyama se sebelisitse litoeba tse nang le phetoho ea liphatsa tsa lefutso e le mohlala oa lefu la Alzheimer.Phetoho ena e fa litoeba litšobotsi tse ling tsa lefu la Alzheimer, ho kenyeletsoa ho fokotseha ha mohopolo le ho bokellana ha liprotheine tse itseng bokong, tse bitsoang liprotheine tsa amyloid le tau.
"Re tlaleha leano le hlophisitsoeng la ho lekola bakuli ba bioactive meriana ea tlhaho e sebelisetsoang lefu la Alzheimer's (AD)," bangoli ba ngotse."Re fumane hore Drynaria rhizome e ka ntlafatsa ts'ebetso ea mohopolo le ho ntlafatsa li-pathologies tsa AD ho litoeba tsa 5XFAD.Tlhahlobo ea lik'hemik'hale e lebisitse ho khethoeng ha metabolite ea bioeffective e fetisetsoang bokong, e leng, naringenin le glucuronides ea eona.Ho hlahloba mokhoa oa ts'ebetso, re ile ra kopanya botsitso ba sepheo sa ho sebetsana le lithethefatsi le tlhahlobo ea immunoprecipitation-liquid chromatography/mass spectrometry, ho khetholla protheine ea collapsin reaction mediator 2 (CRMP2) e le sepheo sa naringenin."
Bo-rasaense ba fumane hore semela se ntšitsoeng se fokolitse ho senyeha ha mohopolo le maemo a liprotheine tsa amyloid le tau bokong ba litoeba.Ho feta moo, sehlopha se ile sa hlahloba lisele tsa boko ba mouse ka mor'a lihora tse hlano ka mor'a hore li phekole litoeba ka moqomo.Ba ile ba fumana hore metsoako e meraro ea semela sena e entse hore e kene bokong—naringenin le metabolite e ’meli ea naringenin.
Ha bafuputsi ba tšoara litoeba ka naringenin e hloekileng, ba ile ba hlokomela lintlafatso tse tšoanang le ho haelloa ke mohopolo le ho fokotseha ha liprotheine tsa amyloid le tau, ho bolelang hore naringenin le metabolites ea eona e ka 'na eaba ke metsoako e sebetsang ka har'a semela.Ba fumane protheine e bitsoang CRMP2 eo naringenin e tlamellang ho eona ho li-neuron, e leng se etsang hore li hōle, li fana ka maikutlo a hore ona e ka ba mokhoa oo naringenin e ka ntlafatsang matšoao a lefu la Alzheimer's.
Bafuputsi ba na le tšepo ea hore mokhoa ona o mocha o ka sebelisoa ho khetholla mekhoa e meng ea phekolo.Dr. Tohda o ile a hlokomela: “Re sebelisa mokhoa ona ho sibolla meriana e mecha bakeng sa mafu a mang a kang lesapo la mokokotlo, ho tepella maikutlong le lefu la sarcopenia.
Nako ea poso: Mar-23-2022