An yi amfani da tsire-tsire na magani na gargajiya a cikin shekaru don ba da haske game da tarin cututtuka.Duk da haka ware takamaiman kwayoyin halitta masu tasiri daga mahallin mahadi waɗanda suka ƙunshi yawancin nau'in shuka na iya zama ɗawainiya mai ban tsoro.Yanzu, masu bincike a Jami'ar Toyama, Japan sun ɓullo da wata hanya don ware da gano abubuwan da ke aiki a cikin magungunan shuka.
Sabbin bayanai-wanda aka buga kwanan nan a cikin Frontiers in Pharmacology a cikin labarin mai suna, "Dabarar Tsare-tsare don Gano Maganin warkewa don Cutar Alzheimer da Kwayoyin Manufansa", nuna cewa wani sabon dabara gano da dama aiki mahadi daga Drynaria rhizome, wani gargajiya shuka magani, cewa inganta memory da kuma rage cututtuka halaye a cikin linzamin kwamfuta model na cutar Alzheimer.
Yawanci, masana kimiyya za su yi ta tantance magungunan tsiro a cikin gwaje-gwajen dakin gwaje-gwaje don ganin ko wasu mahadi suna nuna tasiri akan ƙwayoyin da aka girma a cikin vitro.Idan fili ya nuna sakamako mai kyau a cikin sel ko bututun gwaji, ana iya amfani da shi azaman magani, kuma masanan kimiyya sun ci gaba da gwada shi a cikin dabbobi.Duk da haka, wannan tsari yana da wuyar gaske kuma baya lissafin canje-canjen da zasu iya faruwa ga kwayoyi lokacin da suka shiga jiki-enzymes a cikin jini da hanta na iya daidaita kwayoyi zuwa nau'i daban-daban da ake kira metabolites.Bugu da ƙari, wasu wurare na jiki, irin su kwakwalwa, suna da wuyar samun damar yin amfani da magunguna da yawa, kuma wasu magunguna ne kawai ko abubuwan da suka dace za su shiga waɗannan kyallen takarda.
"Magungunan 'yan takarar da aka gano a cikin allon magungunan benchtop na gargajiya na magungunan tsire-tsire ba koyaushe ba ne masu aiki masu aiki na gaske saboda waɗannan gwaje-gwajen sunyi watsi da biometabolism da rarraba nama," in ji babban mai binciken Chiihiro Tohda, Ph.D., masanin farfesa na neuropharmacology a Jami'ar Toyama. ."Don haka, mun yi niyya don haɓaka ingantattun hanyoyin don gano ingantattun mahadi masu aiki waɗanda ke yin la'akari da waɗannan abubuwan."
A cikin binciken, ƙungiyar Toyama ta yi amfani da beraye tare da maye gurbin kwayoyin halitta a matsayin abin koyi ga cutar Alzheimer.Wannan maye gurbi yana baiwa berayen wasu halaye na cutar Alzheimer, gami da raguwar ƙwaƙwalwar ajiya da tarin takamaiman sunadaran a cikin kwakwalwa, waɗanda ake kira amyloid da furotin tau.
"Muna ba da rahoton wata dabara don kimanta 'yan takarar bioactive a cikin magungunan halitta da aka yi amfani da su don cutar Alzheimer (AD)," marubutan sun rubuta."Mun gano cewa Drynaria rhizome na iya haɓaka aikin ƙwaƙwalwar ajiya da haɓaka cututtukan AD a cikin mice 5XFAD.Binciken biochemical ya haifar da gano abubuwan da ke da tasiri mai tasiri waɗanda aka canjawa wuri zuwa kwakwalwa, wato, naringenin da glucuronides.Don bincika tsarin aiki, mun haɗu da kwanciyar hankali na kusancin magungunan ƙwayoyi tare da immunoprecipitation-liquid chromatography/mass spectrometry analysis, gano furotin mai shiga tsakani na 2 (CRMP2) furotin a matsayin makasudin naringenin.
Masanan kimiyyar sun gano cewa tsiron tsiro na rage ƙwaƙƙwaran ƙwaƙwalwar ajiya da matakan furotin amyloid da tau a cikin kwakwalwar linzamin kwamfuta.Bugu da ƙari, ƙungiyar ta bincika ƙwayar kwakwalwar linzamin kwamfuta sa'o'i biyar bayan sun yi amfani da berayen tare da cirewa.Sun gano cewa mahadi guda uku daga shuka sun sanya ta cikin kwakwalwa - naringenin da naringenin metabolites guda biyu.
Lokacin da masu binciken suka bi da berayen tare da naringenin mai tsabta, sun lura da irin wannan cigaba a cikin ƙarancin ƙwaƙwalwar ajiya da raguwa a cikin furotin amyloid da tau, yana nuna cewa naringenin da metabolites na iya zama mahadi masu aiki a cikin shuka.Sun sami wani sunadaran da ake kira CRMP2 wanda naringenin ke ɗaure a cikin ƙwayoyin jijiyoyin jiki, wanda ke sa su girma, yana nuna cewa wannan na iya zama hanyar da naringenin zai iya inganta alamun cutar Alzheimer.
Masu binciken suna da kyakkyawan fata cewa za a iya amfani da sabuwar dabarar don gano wasu jiyya."Muna amfani da wannan hanyar don gano sababbin magunguna don wasu cututtuka irin su raunin kashin baya, damuwa, da sarcopenia," in ji Dokta Tohda.
Lokacin aikawa: Maris 23-2022