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Berberine hcl is a yellow crystalline powder, odorless and bitter. Berberine hcl for antibiotic, mainly used in intestinal infection and clinical bacillary dysentery, etc., for dysentery bacillus, escherichia coli, pneumonic diplococcus, s. aureus, streptococcus pneumoniae, salmonella typhi and amoeba has inhibitory effect. It also found that the drug has an anti-arrhythmia effect. Berberine hcl has strong anti-tumor activity in vivo and can induce B16 cell differentiation. Berberine hcl has a synergistic effect on the body in vitro.